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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T5319	Rimeporide EMD-87580	Sodium Channel	Membrane transporter/Ion channel
	Rimeporide (EMD-87580) 是有效的 Na+/H+交换泵 (NHE-1) 选择性抑制剂。
T2238	Cariporide 卡立泊来德,HOE-642	Sodium Channel	Membrane transporter/Ion channel
	Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。
T5333	Rimeporide hydrochloride 盐酸Rimeporide,EMD-87580 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Rimeporide hydrochloride (EMD-87580 hydrochloride) 是一种有效的 Na+/H+交换泵(NHE-1) 选择性抑制剂。
T7587	Tenapanor RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722	Sodium Channel	Membrane transporter/Ion channel
	Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。
TQ0157	EIPA L593754,MH 12-43	Sodium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。
T36569	KR-32568	Sodium Channel	Membrane transporter/Ion channel
	KR-32568是一种钠/氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg/kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
T23566	Zoniporide dihydrochloride	Others	Others
	Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor
T14566	BI-9627	Others	Others
	BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).
T13413	Zoniporide hydrochloride hydrate CP-597396 hydrochloride hydrate	Others	Others
	Zoniporide hydrochloride hydrate is a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor. Zoniporide hydrochloride hydrate inhibits human NHE-1 with IC50 of 14 nM.

化合物

Rimeporide

Cat.No: T5319

Synonym: EMD-87580

Target: Sodium Channel

Cariporide

Cat.No: T2238

Synonym: 卡立泊来德,HOE-642

Target: Sodium Channel

Rimeporide hydrochloride

Cat.No: T5333

Synonym: 盐酸Rimeporide,EMD-87580 hydrochloride

Target: Sodium Channel

Tenapanor

Cat.No: T7587

Synonym: RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722

Target: Sodium Channel

EIPA

Cat.No: TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

KR-32568

Cat.No: T36569

Synonym:

Target: Sodium Channel

Zoniporide dihydrochloride

Zoniporide hydrochloride hydrate

Cat.No: T13413

Synonym: CP-597396 hydrochloride hydrate

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1033	Monensin sodium salt 莫能菌素钠盐,Sodium Monensin,Monensin A sodium salt	Sodium Channel; Antibacterial; Antibiotic	Membrane transporter/Ion channel; Microbiology/Virology
	Monensin sodium salt (Monensin A sodium salt) 是由肉桂链霉菌分泌的抗生素。它是一种介导Na+/H+交换的离子载体。它引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。